Graft - Versus - Host - Like Disease - A
نویسندگان
چکیده
Graft-versus-host disease (GVHD) is a T-cell-mediated reaction that most commonly develops after transplantation of hematopoietic stem cells. In rare conditions, GVHD-like symptoms are observed in patients with thymoma. We present the case of a 58-year-old man with thymoma noted 6 years earlier who initially presented with myasthenia gravis and subsequently developed GVHD-like disease with symptoms of generalized itching, scaly erythroderma, and liver dysfunction. The histopathological features of a skin biopsy were consistent with those noted in the case of GVHD. We assume that the altered thymic microenvironment in thymoma patients causes immune dysregulation, leading to GVHD-like disease. (Dermatol Sinica 27: 241-247, 2009)
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